A role for sphingosine kinase 1 in dextran sulfate sodium-induced colitis

The bioactive lipid sphingosine-1-phosphate (S1P) is emerging as an important mediator of immune and inflammatory responses. S1P formation is catalyzed by sphingosine kinase (SK), of which the SK1 isoenzyme is activated by tumor necrosis alpha (TNF-α). SK1 has been shown to be required for mediating...

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Bibliografiske detaljer
Main Authors: Snider, Ashley J., Kawamori, Toshihiko, Bradshaw, Sarah G., Orr, K. Alexa, Gilkeson, Gary S., Hannun, Yusuf A., Obeid, Lina M.
Format: Artigo
Sprog:Inglês
Udgivet: The Federation of American Societies for Experimental Biology 2009
Fag:
Research Communications
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2626622/
https://ncbi.nlm.nih.gov/pubmed/18815359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.08-118109
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