LXR signaling couples sterol metabolism to proliferation in the acquired immune response

We demonstrate here that LXR–dependent sterol homeostasis is a physiologically-regulated determinant of cell proliferation and acquired immune responses. T cell activation triggers simultaneous suppression of the LXR pathway for cholesterol transport and induction of the SREBP pathway for cholestero...

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Autors principals: Bensinger, Steven J., Bradley, Michelle N., Joseph, Sean B., Zelcer, Noam, Janssen, Edith M., Hausner, Mary Ann, Shih, Roger, Parks, John S., Edwards, Peter A., Jamieson, Beth D., Tontonoz, Peter
Format: Artigo
Idioma:Inglês
Publicat: 2008
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2626438/
https://ncbi.nlm.nih.gov/pubmed/18614014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2008.04.052
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