Small-molecule inhibitors of integrin α(2)β(1) that prevent pathological thrombus formation via an allosteric mechanism

There is a grave need for safer antiplatelet therapeutics to prevent heart attack and stroke. Agents targeting the interaction of platelets with the diseased vessel wall could impact vascular disease with minimal effects on normal hemostasis. We targeted integrin α(2)β(1), a collagen receptor, becau...

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Detaylı Bibliyografya
Asıl Yazarlar: Miller, Meredith W., Basra, Sandeep, Kulp, Daniel W., Billings, Paul C., Choi, Sungwook, Beavers, Mary Pat, McCarty, Owen J. T., Zou, Zhiying, Kahn, Mark L., Bennett, Joel S., DeGrado, William F.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2009
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2625282/
https://ncbi.nlm.nih.gov/pubmed/19141632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0811622106
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