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Small-molecule inhibitors of integrin α(2)β(1) that prevent pathological thrombus formation via an allosteric mechanism
There is a grave need for safer antiplatelet therapeutics to prevent heart attack and stroke. Agents targeting the interaction of platelets with the diseased vessel wall could impact vascular disease with minimal effects on normal hemostasis. We targeted integrin α(2)β(1), a collagen receptor, becau...
Gorde:
| Egile Nagusiak: | , , , , , , , , , , |
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
National Academy of Sciences
2009
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2625282/ https://ncbi.nlm.nih.gov/pubmed/19141632 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0811622106 |
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