Small-molecule inhibitors of integrin α(2)β(1) that prevent pathological thrombus formation via an allosteric mechanism

There is a grave need for safer antiplatelet therapeutics to prevent heart attack and stroke. Agents targeting the interaction of platelets with the diseased vessel wall could impact vascular disease with minimal effects on normal hemostasis. We targeted integrin α(2)β(1), a collagen receptor, becau...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Miller, Meredith W., Basra, Sandeep, Kulp, Daniel W., Billings, Paul C., Choi, Sungwook, Beavers, Mary Pat, McCarty, Owen J. T., Zou, Zhiying, Kahn, Mark L., Bennett, Joel S., DeGrado, William F.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2009
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2625282/
https://ncbi.nlm.nih.gov/pubmed/19141632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0811622106
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