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Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative Stress

A common feature of diverse chemopreventive agents is the ability to activate expression of a genetic program that protects cells from reactive chemical species that, if left unchecked, would cause mutagenic DNA damage. The bZIP transcription factor Nrf2 has emerged as a key regulator of this cancer...

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Sonraí Bibleagrafaíochta
Main Authors: Zhang, Donna D., Hannink, Mark
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology 2003
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC262403/
https://ncbi.nlm.nih.gov/pubmed/14585973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.22.8137-8151.2003
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