The DFNA15 Deafness Mutation Affects POU4F3 Protein Stability, Localization, and Transcriptional Activity

A mutation in the POU4F3 gene (BRN-3.1, BRN3C) is responsible for DFNA15 (MIM 602459), autosomal-dominant nonsyndromic hearing loss. POU4F3 is a member of the POU family of transcription factors and is essential for inner-ear hair cell maintenance. To test the potential effects of the human POU4F3 m...

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Detalhes bibliográficos
Main Authors: Weiss, Sigal, Gottfried, Irit, Mayrose, Itay, Khare, Suvarna L., Xiang, Mengqing, Dawson, Sally J., Avraham, Karen B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Transcriptional Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC262385/
https://ncbi.nlm.nih.gov/pubmed/14585957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.22.7957-7964.2003
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