Biochemical Characterization of the Ran-RanBP1-RanGAP System: Are RanBP Proteins and the Acidic Tail of RanGAP Required for the Ran-RanGAP GTPase Reaction?

RanBP type proteins have been reported to increase the catalytic efficiency of the RanGAP-mediated GTPase reaction on Ran. Since the structure of the Ran-RanBP1-RanGAP complex showed RanBP1 to be located away from the active site, we reinvestigated the reaction using fluorescence spectroscopy under...

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Detalhes bibliográficos
Main Authors: Seewald, Michael J., Kraemer, Astrid, Farkasovsky, Marian, Körner, Carolin, Wittinghofer, Alfred, Vetter, Ingrid R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC262373/
https://ncbi.nlm.nih.gov/pubmed/14585972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.22.8124-8136.2003
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