Disappearance of body fat in normal rats induced by adenovirus-mediated leptin gene therapy

Sustained hyperleptinemia of 8 ng/ml was induced for 28 days in normal Wistar rats by infusing a recombinant adenovirus containing the rat leptin cDNA (AdCMV-leptin). Hyperleptinemic rats exhibited a 30–50% reduction in food intake and gained only 22 g over the experimental period versus 115–132 g i...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Chen, Guoxun, Koyama, Kazunori, Yuan, Xue, Lee, Young, Zhou, Yan-Ting, O’Doherty, Robert, Newgard, Christopher B., Unger, Roger H.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1996
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC26215/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8962134/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.25.14795
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