Disappearance of body fat in normal rats induced by adenovirus-mediated leptin gene therapy

Sustained hyperleptinemia of 8 ng/ml was induced for 28 days in normal Wistar rats by infusing a recombinant adenovirus containing the rat leptin cDNA (AdCMV-leptin). Hyperleptinemic rats exhibited a 30–50% reduction in food intake and gained only 22 g over the experimental period versus 115–132 g i...

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Main Authors: Chen, Guoxun, Koyama, Kazunori, Yuan, Xue, Lee, Young, Zhou, Yan-Ting, O’Doherty, Robert, Newgard, Christopher B., Unger, Roger H.
Formáid: Artigo
Teanga:Inglês
Foilsithe: The National Academy of Sciences of the USA 1996
Ábhair:
Biological Sciences
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC26215/
https://ncbi.nlm.nih.gov/pubmed/8962134
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