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Molecular ordering of the Fas-apoptotic pathway: The Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases

The Fas/APO-1-receptor associated cysteine protease Mch5 (MACH/FLICE) is believed to be the enzyme responsible for activating a protease cascade after Fas-receptor ligation, leading to cell death. The Fas-apoptotic pathway is potently inhibited by the cowpox serpin CrmA, suggesting that Mch5 could b...

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Autori principali: Srinivasula, Srinivasa M., Ahmad, Manzoor, Fernandes-Alnemri, Teresa, Litwack, Gerald, Alnemri, Emad S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The National Academy of Sciences of the USA 1996
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC26159/
https://ncbi.nlm.nih.gov/pubmed/8962078
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