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Molecular ordering of the Fas-apoptotic pathway: The Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases

The Fas/APO-1-receptor associated cysteine protease Mch5 (MACH/FLICE) is believed to be the enzyme responsible for activating a protease cascade after Fas-receptor ligation, leading to cell death. The Fas-apoptotic pathway is potently inhibited by the cowpox serpin CrmA, suggesting that Mch5 could b...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Srinivasula, Srinivasa M., Ahmad, Manzoor, Fernandes-Alnemri, Teresa, Litwack, Gerald, Alnemri, Emad S.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1996
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC26159/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8962078/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.25.14486
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