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The exosome contains domains with specific endoribonuclease, exoribonuclease and cytoplasmic mRNA decay activities

The eukaryotic exosome is a ten subunit 3′ exoribonuclease complex responsible for many RNA processing and degradation reactions. How the exosome accomplishes this is unknown. We show that the PIN domain of Rrp44 is an endoribonuclease. The activity of the PIN domain prefers RNA with a 5′ phosphate,...

詳細記述

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書誌詳細
主要な著者: Schaeffer, Daneen, Tsanova, Borislava, Barbas, Ana, Reis, Filipa Pereira, Dastidar, Eeshita Ghosh, Sanchez-Rotunno, Maya, Arraiano, Cecilia Maria, van Hoof, Ambro
フォーマット: Artigo
言語:Inglês
出版事項: 2008
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2615074/
https://ncbi.nlm.nih.gov/pubmed/19060898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1528
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