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Generation of Novel Pikromycin Antibiotic Products Through Mutasynthesis
Mutasynthesis in pikromycin PKS: The amenability of pikromycin polyketide synthase to mutational biosynthesis has been demonstrated. A natural triketide and its analogues, activated as N-acetyl-cysteamine thioesters, were synthesized and fed to a pikAI-deleted strain; this led to the production of n...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2008
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2614871/ https://ncbi.nlm.nih.gov/pubmed/18512859 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.200700635 |
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