HDAC2 blockade by nitric oxide and histone deacetylase inhibitors reveals a common target in Duchenne muscular dystrophy treatment

The overlapping histological and biochemical features underlying the beneficial effect of deacetylase inhibitors and NO donors in dystrophic muscles suggest an unanticipated molecular link among dystrophin, NO signaling, and the histone deacetylases (HDACs). Higher global deacetylase activity and se...

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Bibliografski detalji
Glavni autori: Colussi, Claudia, Mozzetta, Chiara, Gurtner, Aymone, Illi, Barbara, Rosati, Jessica, Straino, Stefania, Ragone, Gianluca, Pescatori, Mario, Zaccagnini, Germana, Antonini, Annalisa, Minetti, Giulia, Martelli, Fabio, Piaggio, Giulia, Gallinari, Paola, Steinkuhler, Christian, Clementi, Emilio, Dell'Aversana, Carmela, Altucci, Lucia, Mai, Antonello, Capogrossi, Maurizio C., Puri, Pier Lorenzo, Gaetano, Carlo
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2008
Teme:
Biological Sciences
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2614736/
https://ncbi.nlm.nih.gov/pubmed/19047631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0805514105
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