Mutation in the DC-SIGN cytoplasmic triacidic cluster motif markedly attenuates receptor activity for phagocytosis and endocytosis of mannose-containing ligands by human myeloid cells

The transmembrane C-type lectin, dendritic cell-specific ICAM-3-grabbing nonintegrin (DC-SIGN), has three conserved cytoplasmic tail motifs: the tyrosine (Y)-based, dileucine (LL), and triacidic cluster (EEE), which are believed to regulate ligand binding, uptake, and trafficking. We mutated each of...

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Bibliographic Details
Main Authors: Azad, Abul K., Torrelles, Jordi B., Schlesinger, Larry S.
Format: Artigo
Language:Inglês
Published: The Society for Leukocyte Biology 2008
Subjects:
Receptors, Signal Transduction, and Genes
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2614595/
https://ncbi.nlm.nih.gov/pubmed/18772280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.0308192
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