The human macrophage mannose receptor directs Mycobacterium tuberculosis lipoarabinomannan-mediated phagosome biogenesis

Mycobacterium tuberculosis (M.tb) survives in macrophages in part by limiting phagosome–lysosome (P-L) fusion. M.tb mannose-capped lipoarabinomannan (ManLAM) blocks phagosome maturation. The pattern recognition mannose receptor (MR) binds to the ManLAM mannose caps and mediates phagocytosis of bacil...

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Detalhes bibliográficos
Main Authors: Kang, Peter B., Azad, Abul K., Torrelles, Jordi B., Kaufman, Thomas M., Beharka, Alison, Tibesar, Eric, DesJardin, Lucy E., Schlesinger, Larry S.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2005
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2213176/
https://ncbi.nlm.nih.gov/pubmed/16203868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20051239
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