Differential Mechanisms in the Pathogenesis of Autoimmune Cholangitis Versus IBD in IL-2Rα(-/-) Mice

IL-2 receptor α knockout (IL-2Rα(-/-)) mice have a deficiency of CD25 and a corresponding functional defect in T regulatory cells (Treg). These mice spontaneously develop portal inflammation with biliary ductular damage and colitis with features similar to human inflammatory bowel disease (IBD) with...

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Hlavní autoři: Hsu, Willy, Zhang, Weici, Tsuneyama, Koichi, Moritoki, Yuki, Ridgway, William M., Ansari, Aftab A., Coppel, Ross L., Lian, Zhe-Xiong, Mackay, Ian, Gershwin, M. Eric
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2614451/
https://ncbi.nlm.nih.gov/pubmed/19065673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.22591
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