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The role of the PI3K-AKT kinase pathway in T cell development beyond the β checkpoint
The PI3K-AKT pathway can mediate diverse biological responses and is crucial for optimal immune responses and lymphocyte development. Deletion of PI3K subunits or AKT leads to blockage of T cell development at the TCRβ checkpoint. Studies with over-expression of constitutively activated AKT have imp...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2614442/ https://ncbi.nlm.nih.gov/pubmed/18991293 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.200838614 |
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