Pharmacologic and Genetic Manipulation of Matrix Metalloproteinases -2 and -9 Reduce Retinal Neovascularization in Rodent Models of Retinopathy of Prematurity

PURPOSE: In order to examine the roles of MMP-2 and MMP-9 in retinal neovascularization, the efficacy of three matrix metalloproteinase (MMP) inhibitors with varying selectivity, (Ro-31-9790, AG3340 and DPC-A37668) was investigated in a rat model of retinopathy of prematurity. The susceptibilities o...

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Главные авторы: Barnett, Joshua M., McCollum, Gary W., Fowler, Jessica A., Duan, James J.-W., Kay, Jesse D., Liu, Rui-Qin, Bingaman, David P., Penn, John S.
Формат: Artigo
Язык:Inglês
Опубликовано: 2007
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2614400/
https://ncbi.nlm.nih.gov/pubmed/17251494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.06-0082
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