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Hirschsprung Disease Is Linked to Defects in Neural Crest Stem Cell Function

Genes associated with Hirschsprung disease, a failure to form enteric ganglia in the hindgut, were highly up-regulated in gut neural crest stem cells relative to whole-fetus RNA. One of these genes, the glial cell line– derived neurotrophic factor (GDNF) receptor Ret, was necessary for neural crest...

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Bibliografski detalji
Glavni autori: Iwashita, Toshihide, Kruger, Genevieve M., Pardal, Ricardo, Kiel, Mark J., Morrison, Sean J.
Format: Artigo
Jezik:Inglês
Izdano: 2003
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2614078/
https://ncbi.nlm.nih.gov/pubmed/12920301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1085649
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