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Hirschsprung Disease Is Linked to Defects in Neural Crest Stem Cell Function
Genes associated with Hirschsprung disease, a failure to form enteric ganglia in the hindgut, were highly up-regulated in gut neural crest stem cells relative to whole-fetus RNA. One of these genes, the glial cell line– derived neurotrophic factor (GDNF) receptor Ret, was necessary for neural crest...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2614078/ https://ncbi.nlm.nih.gov/pubmed/12920301 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1085649 |
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