Action Potential Dynamics Explain Arrhythmic Vulnerability in Human Heart Failure: A Clinical and Modeling Study Implicating Abnormal Calcium Handling

OBJECTIVE: To determine whether abnormalities of calcium cycling explain ventricular action potential (AP) oscillations and cause ECG T-wave Alternans (TWA). BACKGROUND: Mechanisms explaining why heart failure patients are at risk for malignant ventricular arrhythmias (VT/VF) are unclear. We studied...

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Main Authors: Narayan, Sanjiv M., Bayer, Jason D., Lalani, Gautam, Trayanova, Natalia A.
Format: Artigo
Jezik:Inglês
Izdano: 2008
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2613952/
https://ncbi.nlm.nih.gov/pubmed/19022157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacc.2008.08.037
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