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DNA TOPOISOMERASE I INHIBITORS AMELIORATE SEIZURE-LIKE BEHAVIORS AND PARALYSIS IN A DROSOPHILA MODEL OF EPILEPSY
The Drosophila DNA topoisomerase type I mutant allele, top1(JS) is an effective general seizure-suppressor mutation, reverting seizure-sensitive phenotypes of several mutant strains in a genetic model of epilepsy. Seizure-suppression is caused by reduced transcription of the top1 gene (Song et al.,...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2008
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2613863/ https://ncbi.nlm.nih.gov/pubmed/18703119 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2008.07.024 |
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