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Drosophila as a Model for Epilepsy: bss Is a Gain-of-Function Mutation in the Para Sodium Channel Gene That Leads to Seizures

We report the identification of bang senseless (bss), a Drosophila melanogaster mutant exhibiting seizure-like behaviors, as an allele of the paralytic (para) voltage-gated Na(+) (Na(V)) channel gene. Mutants are more prone to seizure episodes than normal flies because of a lowered seizure threshold...

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Detalhes bibliográficos
Main Authors: Parker, Louise, Padilla, Miguel, Du, Yuzhe, Dong, Ke, Tanouye, Mark A.
Formato: Artigo
Idioma:Inglês
Publicado em: Genetics Society of America 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3030494/
https://ncbi.nlm.nih.gov/pubmed/21115970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.110.123299
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