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Seizure Suppression by top1 Mutations in Drosophila

DNA topoisomerase I is an essential nuclear enzyme involved in resolving the torsional stress associated with DNA replication, transcription, and chromatin condensation. Here we report the discovery of a seizure-suppressor mutant, top1(JS), which suppresses seizures in a Drosophila model of human ep...

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Bibliografiske detaljer
Udgivet i:J Neurosci
Main Authors: Song, Juan, Hu, Joyce, Tanouye, Mark
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2007
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6672588/
https://ncbi.nlm.nih.gov/pubmed/17360915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3944-06.2007
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