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Seizure Suppression by top1 Mutations in Drosophila
DNA topoisomerase I is an essential nuclear enzyme involved in resolving the torsional stress associated with DNA replication, transcription, and chromatin condensation. Here we report the discovery of a seizure-suppressor mutant, top1(JS), which suppresses seizures in a Drosophila model of human ep...
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| 出版年: | J Neurosci |
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| 主要な著者: | , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Society for Neuroscience
2007
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6672588/ https://ncbi.nlm.nih.gov/pubmed/17360915 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3944-06.2007 |
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