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Collaboration between Hepatic and Intratumoral Prodrug Activation in a P450 Prodrug-activation Gene Therapy Model for Cancer Treatment

Presently, we investigate the mechanisms whereby intratumoral expression of a cyclophosphamide (CPA)-activating hepatic cytochrome P450 gene enhances therapeutic activity when CPA is given on an every 6-day (metronomic) schedule. In P450-deficient 9L gliosarcomas grown in scid mice, metronomic CPA s...

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Detalhes bibliográficos
Main Authors: Ma, Jie, Waxman, David J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2613795/
https://ncbi.nlm.nih.gov/pubmed/17989319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-07-0297
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