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Enhancement of Intratumoral Cyclophosphamide Pharmacokinetics and Anti-tumor Activity in a P450 2B11-based Cancer Gene Therapy Model
The therapeutic utility of cytochrome P450-based enzyme prodrug therapy is well established by preclinical studies and in initial clinical trials. The underlying premise of this gene therapy is that intratumoral P450 expression leads to in situ activation of anti-cancer P450 prodrugs, such as cyclop...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2613860/ https://ncbi.nlm.nih.gov/pubmed/17853921 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.cgt.7701092 |
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