Phosphatidylinositol 3-Kinase Pathway Regulates Hypoxia-Inducible Factor-1 to Protect from Intestinal Injury during Necrotizing Enterocolitis

BACKGROUND: Hypoxia is an important risk factor for development of necrotizing enterocolitis (NEC) in premature infants. Hypoxia-inducible factor (HIF)-1 is a transcription factor that plays a critical role in cellular responses to hypoxia and can be induced by phosphatidylinositol 3-kinase (PI3-K)...

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Autors principals: Baregamian, Naira, Rychahou, Piotr G., Hawkins, Hal K., Evers, Mark B., Chung, Dai H.
Format: Artigo
Idioma:Inglês
Publicat: 2007
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2613757/
https://ncbi.nlm.nih.gov/pubmed/17689699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.surg.2007.04.018
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