Rare loss-of-function mutations in ANGPTL family members contribute to plasma triglyceride levels in humans

The relative activity of lipoprotein lipase (LPL) in different tissues controls the partitioning of lipoprotein-derived fatty acids between sites of fat storage (adipose tissue) and oxidation (heart and skeletal muscle). Here we used a reverse genetic strategy to test the hypothesis that 4 angiopoie...

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Main Authors: Romeo, Stefano, Yin, Wu, Kozlitina, Julia, Pennacchio, Len A., Boerwinkle, Eric, Hobbs, Helen H., Cohen, Jonathan C.
格式: Artigo
語言:Inglês
出版: American Society for Clinical Investigation 2008
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2613476/
https://ncbi.nlm.nih.gov/pubmed/19075393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI37118
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