Promoter hypermethylation of the SFRP2 gene is a high-frequent alteration and tumor-specific epigenetic marker in human breast cancer

BACKGROUND: We have previously reported that expression of the Wnt antagonist genes SFRP1 and SFRP5 is frequently silenced by promoter hypermethylation in breast cancer. SFRP2 is a further Wnt inhibitor whose expression was recently found being downregulated in various malignancies. Here we investig...

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Main Authors: Veeck, Jürgen, Noetzel, Erik, Bektas, Nuran, Jost, Edgar, Hartmann, Arndt, Knüchel, Ruth, Dahl, Edgar
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2008
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2613402/
https://ncbi.nlm.nih.gov/pubmed/18990230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-7-83
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