Wnt signalling in human breast cancer: expression of the putative Wnt inhibitor Dickkopf-3 (DKK3) is frequently suppressed by promoter hypermethylation in mammary tumours

INTRODUCTION: Expression of the putative Wnt signalling inhibitor Dickkopf-3 (DKK3) is frequently lost in human cancer tissues because of aberrant 5'-cytosine methylation within the DKK3 gene promoter. Since other Wnt signalling inhibitors have been reported to be targets of epigenetic inactiva...

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Detalhes bibliográficos
Main Authors: Veeck, Jürgen, Bektas, Nuran, Hartmann, Arndt, Kristiansen, Glen, Heindrichs, Uwe, Knüchel, Ruth, Dahl, Edgar
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2614517/
https://ncbi.nlm.nih.gov/pubmed/18826564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr2151
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