Partial Order Optimum Likelihood (POOL): Maximum Likelihood Prediction of Protein Active Site Residues Using 3D Structure and Sequence Properties

A new monotonicity-constrained maximum likelihood approach, called Partial Order Optimum Likelihood (POOL), is presented and applied to the problem of functional site prediction in protein 3D structures, an important current challenge in genomics. The input consists of electrostatic and geometric pr...

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Detalles Bibliográficos
Main Authors: Tong, Wenxu, Wei, Ying, Murga, Leonel F., Ondrechen, Mary Jo, Williams, Ronald J.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2009
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2612599/
https://ncbi.nlm.nih.gov/pubmed/19148270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1000266
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