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Partial Order Optimum Likelihood (POOL): Maximum Likelihood Prediction of Protein Active Site Residues Using 3D Structure and Sequence Properties

A new monotonicity-constrained maximum likelihood approach, called Partial Order Optimum Likelihood (POOL), is presented and applied to the problem of functional site prediction in protein 3D structures, an important current challenge in genomics. The input consists of electrostatic and geometric pr...

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Main Authors: Tong, Wenxu, Wei, Ying, Murga, Leonel F., Ondrechen, Mary Jo, Williams, Ronald J.
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2009
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2612599/
https://ncbi.nlm.nih.gov/pubmed/19148270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1000266
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