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Clinical Outcomes, Safety, and Pharmacokinetics of OPT-80 in a Phase 2 Trial with Patients with Clostridium difficile Infection

OPT-80, a novel, minimally absorbed macrocycle, is a candidate treatment option for Clostridium difficile infection (CDI) based on cure without recurrence of CDI in the hamster challenge model, good in vitro activity against C. difficile, and relative sparing of commensal gram-negative anaerobes. In...

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Hlavní autoři: Louie, T., Miller, M., Donskey, C., Mullane, K., Goldstein, E. J. C.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2009
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2612138/
https://ncbi.nlm.nih.gov/pubmed/18955525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01442-07
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