Common thiolation mechanism in the biosynthesis of tRNA thiouridine and sulphur-containing cofactors

2-Thioribothymidine (s(2)T), a modified uridine, is found at position 54 in transfer RNAs (tRNAs) from several thermophiles; s(2)T stabilizes the L-shaped structure of tRNA and is essential for growth at higher temperatures. Here, we identified an ATPase (tRNA-two-thiouridine C, TtuC) required for t...

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Main Authors: Shigi, Naoki, Sakaguchi, Yuriko, Asai, Shin-ichi, Suzuki, Tsutomu, Watanabe, Kimitsuna
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2008
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2609741/
https://ncbi.nlm.nih.gov/pubmed/19037260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.246
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