Simultaneous blockade of AP-1 and phosphatidylinositol 3-kinase pathway in non-small cell lung cancer cells

c-Jun is a major constituent of AP-1 transcription factor that transduces multiple mitogen growth signals, and it is frequently overexpressed in non-small cell lung cancers (NSCLCs). Earlier, we showed that blocking AP-1 by the overexpression of a c-Jun dominant-negative mutant, TAM67, inhibited NSC...

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Bibliographic Details
Main Authors: Kikuchi, J, Kinoshita, I, Shimizu, Y, Oizumi, S, Nishimura, M, Birrer, M J, Dosaka-Akita, H
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2008
Subjects:
Translational Therapeutics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2607224/
https://ncbi.nlm.nih.gov/pubmed/19018257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6604782
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