Aberrant chromatin at genes encoding stem cell regulators in human mixed-lineage leukemia

Mixed-lineage leukemia (MLL) fusion proteins are potent inducers of leukemia, but how these proteins generate aberrant gene expression programs is poorly understood. Here we show that the MLL-AF4 fusion protein occupies developmental regulatory genes important for hematopoietic stem cell identity an...

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Main Authors: Guenther, Matthew G., Lawton, Lee N., Rozovskaia, Tatiana, Frampton, Garrett M., Levine, Stuart S., Volkert, Thomas L., Croce, Carlo M., Nakamura, Tatsuya, Canaani, Eli, Young, Richard A.
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 2008
Teme:
Research Communication
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2607073/
https://ncbi.nlm.nih.gov/pubmed/19141473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1741408
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