An Unusual Helix Turn Helix Motif in the Catalytic Core of HIV-1 Integrase Binds Viral DNA and LEDGF

BACKGROUND: Integrase (IN) of the type 1 human immunodeficiency virus (HIV-1) catalyzes the integration of viral DNA into host cellular DNA. We identified a bi-helix motif (residues 149–186) in the crystal structure of the catalytic core (CC) of the IN-Phe185Lys variant that consists of the α(4) and...

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Detalhes bibliográficos
Main Authors: Merad, Hayate, Porumb, Horea, Zargarian, Loussiné, René, Brigitte, Hobaika, Zeina, Maroun, Richard G., Mauffret, Olivier, Fermandjian, Serge
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2607020/
https://ncbi.nlm.nih.gov/pubmed/19119323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0004081
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