Iodine Atoms: A New Molecular Feature for the Design of Potent Transthyretin Fibrillogenesis Inhibitors

The thyroid hormone and retinol transporter protein known as transthyretin (TTR) is in the origin of one of the 20 or so known amyloid diseases. TTR self assembles as a homotetramer leaving a central hydrophobic channel with two symmetrical binding sites. The aggregation pathway of TTR into amiloid...

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Auteurs principaux: Mairal, Teresa, Nieto, Joan, Pinto, Marta, Almeida, Maria Rosário, Gales, Luis, Ballesteros, Alfredo, Barluenga, José, Pérez, Juan J., Vázquez, Jesús T., Centeno, Nuria B., Saraiva, Maria Joao, Damas, Ana M., Planas, Antoni, Arsequell, Gemma, Valencia, Gregorio
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2009
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2607018/
https://ncbi.nlm.nih.gov/pubmed/19125186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0004124
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