Iodine Atoms: A New Molecular Feature for the Design of Potent Transthyretin Fibrillogenesis Inhibitors

The thyroid hormone and retinol transporter protein known as transthyretin (TTR) is in the origin of one of the 20 or so known amyloid diseases. TTR self assembles as a homotetramer leaving a central hydrophobic channel with two symmetrical binding sites. The aggregation pathway of TTR into amiloid...

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Autori principali: Mairal, Teresa, Nieto, Joan, Pinto, Marta, Almeida, Maria Rosário, Gales, Luis, Ballesteros, Alfredo, Barluenga, José, Pérez, Juan J., Vázquez, Jesús T., Centeno, Nuria B., Saraiva, Maria Joao, Damas, Ana M., Planas, Antoni, Arsequell, Gemma, Valencia, Gregorio
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2009
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2607018/
https://ncbi.nlm.nih.gov/pubmed/19125186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0004124
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