The sympathetic tone mediates leptin's inhibition of insulin secretion by modulating osteocalcin bioactivity

The osteoblast-secreted molecule osteocalcin favors insulin secretion, but how this function is regulated in vivo by extracellular signals is for now unknown. In this study, we show that leptin, which instead inhibits insulin secretion, partly uses the sympathetic nervous system to fulfill this func...

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Bibliografische gegevens
Hoofdauteurs: Hinoi, Eiichi, Gao, Nan, Jung, Dae Young, Yadav, Vijay, Yoshizawa, Tatsuya, Myers, Martin G., Chua, Streamson C., Kim, Jason K., Kaestner, Klaus H., Karsenty, Gerard
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The Rockefeller University Press 2008
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Research Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2606962/
https://ncbi.nlm.nih.gov/pubmed/19103808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200809113
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