The sympathetic tone mediates leptin's inhibition of insulin secretion by modulating osteocalcin bioactivity

The osteoblast-secreted molecule osteocalcin favors insulin secretion, but how this function is regulated in vivo by extracellular signals is for now unknown. In this study, we show that leptin, which instead inhibits insulin secretion, partly uses the sympathetic nervous system to fulfill this func...

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Autors principals: Hinoi, Eiichi, Gao, Nan, Jung, Dae Young, Yadav, Vijay, Yoshizawa, Tatsuya, Myers, Martin G., Chua, Streamson C., Kim, Jason K., Kaestner, Klaus H., Karsenty, Gerard
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2008
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2606962/
https://ncbi.nlm.nih.gov/pubmed/19103808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200809113
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