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Blocking Pore-open Mutants of CLC-0 by Amphiphilic Blockers
The blockade of CLC-0 chloride channels by p-chlorophenoxy acetate (CPA) has been thought to be state dependent; the conformational change of the channel pore during the “fast gating” alters the CPA binding affinity. Here, we examine the mechanism of CPA blocking in pore-open mutants of CLC-0 in whi...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2606940/ https://ncbi.nlm.nih.gov/pubmed/19088381 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.200810004 |
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