Sodium-Dependent Multivitamin Transporter Gene Is Regulated at the Chromatin Level by Histone Biotinylation in Human Jurkat Lymphoblastoma Cells

The sodium-dependent multivitamin transporter (SMVT) is essential for mediating and regulating biotin entry into mammalian cells. In cells, holocarboxylase synthetase (HCS) mediates covalent binding of biotin to histones; biotinylation of lysine-12 in histone H4 (K12BioH4) causes gene repression. He...

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Bibliografiske detaljer
Main Authors: Zempleni, Janos, Gralla, Michael, Camporeale, Gabriela, Hassan, Yousef I.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Nutrition 2009
Fag:
Symposium: Advances in Understanding of the Biological Role of Biotin at the Clinical, Biochemical, and Molecular Level
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2606921/
https://ncbi.nlm.nih.gov/pubmed/19056636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3945/jn.108.091967
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