All-trans Retinoic Acid Inhibits Type 1 Diabetes by T Regulatory (Treg)-Dependent Suppression of Interferon-γ–Producing T-cells Without Affecting Th17 Cells

OBJECTIVE—All-trans retinoic acid (ATRA), a potent derivative of vitamin A, can regulate immune responses. However, its role in inducing immune tolerance associated with the prevention of islet inflammation and inhibition of type 1 diabetes remains unclear. RESEARCH DESIGN AND METHODS—We investigate...

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Main Authors: Van, Yang-Hau, Lee, Wen-Hui, Ortiz, Serina, Lee, Mi-Heon, Qin, Han-Jun, Liu, Chih-Pin
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Diabetes Association 2009
Ábhair:
Immunology and Transplantation
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2606864/
https://ncbi.nlm.nih.gov/pubmed/18984738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db08-1154
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