Growing tumors induce hypersensitivity to endotoxin and tumor necrosis factor.

Lewis lung carcinoma and EMT6 sarcoma growing as solid tumors in mice caused a gradual increase in the susceptibility of the animals to lethal toxicity of endotoxins (lipopolysaccharides [LPS]). By day 15 following inoculation of the tumors, the 50% lethal dose of LPS, which in normal mice was appro...

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Main Authors: Bartholeyns, J, Freudenberg, M, Galanos, C
Format: Artigo
Sprog:Inglês
Udgivet: 1987
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC260683/
https://ncbi.nlm.nih.gov/pubmed/3623699
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