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p53-inducible ribonucleotide reductase (p53R2/RRM2B) is a DNA hypomethylation-independent decitabine gene target that correlates with clinical response in MDS/AML

While the therapeutic activity of the deoxycytidine analog decitabine is thought to reflect its ability to reactivate methylation-silenced genes, this agent is also known to trigger p53-dependent DNA damage responses. Here we report that p53-inducible ribonucleotide reductase (p53R2/RRM2B) is a robu...

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Detalhes bibliográficos
Main Authors: Link, Petra A., Baer, Maria R., James, Smitha R., Jones, David A., Karpf, Adam R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2606040/
https://ncbi.nlm.nih.gov/pubmed/19010910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-1860
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