Incomplete Inhibition of Sphingosine 1-Phosphate Lyase Modulates Immune System Function yet Prevents Early Lethality and Non-Lymphoid Lesions

BACKGROUND: S1PL is an aldehyde-lyase that irreversibly cleaves sphingosine 1-phosphate (S1P) in the terminal step of sphingolipid catabolism. Because S1P modulates a wide range of physiological processes, its concentration must be tightly regulated within both intracellular and extracellular enviro...

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Main Authors: Vogel, Peter, Donoviel, Michael S., Read, Robert, Hansen, Gwenn M., Hazlewood, Jill, Anderson, Stephen J., Sun, Weimei, Swaffield, Jonathan, Oravecz, Tamas
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2009
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2606024/
https://ncbi.nlm.nih.gov/pubmed/19119317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0004112
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