Nonobese Diabetic Mouse Congenic Analysis Reveals Chromosome 11 Locus Contributing to Diabetes Susceptibility, Macrophage STAT5 Dysfunction, and Granulocyte-Macrophage Colony-Stimulating Factor Overproduction

Unstimulated monocytes of at-risk/type 1 diabetic humans and macrophages of the NOD mouse have markedly elevated autocrine GM-CSF production and persistent STAT5 phosphorylation. We analyzed the relationship between GM-CSF production and persistent STAT5 phosphorylation in NOD macrophages using reci...

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Main Authors: Litherland, Sally A., Grebe, Kristie M., Belkin, Nicole S., Paek, Edward, Elf, Jessica, Atkinson, Mark, Morel, Laurence, Clare-Salzler, Michael J., McDuffie, Marcia
Formato: Artigo
Idioma:Inglês
Publicado em: 2005
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2605964/
https://ncbi.nlm.nih.gov/pubmed/16177100
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