Morphine Exacerbates HIV-1 Tat-Induced Cytokine Production in Astrocytes through Convergent Effects on [Ca(2+)](i), NF-κB Trafficking and Transcription

Astroglia are key cellular sites where opiate drug signals converge with the proinflammatory effects of HIV-1 Tat signals to exacerbate HIV encephalitis. Despite this understanding, the molecular sites of convergence driving opiate-accelerated neuropathogenesis have not been deciphered. We therefore...

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Detalhes bibliográficos
Main Authors: El-Hage, Nazira, Bruce-Keller, Annadora J., Yakovleva, Tatiana, Bazov, Igor, Bakalkin, Georgy, Knapp, Pamela E., Hauser, Kurt F.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2605563/
https://ncbi.nlm.nih.gov/pubmed/19116667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0004093
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